Use cases /
Aid Clinical Trials

Environmental data for every stage of a trial, in one place

From site selection to submission, environmental conditions greatly shape trial outcomes. Ambee helps at every stage.

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Environmental conditions affect outcomes, comparability, and regulatory confidence

Multi-site trials span geographies with different pollen, air quality, temperature, and seasonal profiles. In respiratory, allergy, dermatology, and inflammatory indications, these conditions function as extrinsic covariates. They influence symptom burden and patient-reported outcomes, shift symptom severity within assessment windows, and contribute to inter-site variability. Left unaddressed, that variability can surface in primary endpoint data.

In field studies, variable allergen exposure and confounding environmental factors (rain, dust, other allergens, etc.), and allergen exposure avoidance by participants can influence the treatment effect in field studies.
Simeon Powers
Director - Product Marketing | Ad Management
Ambee addresses this at every stage of a trial, from site selection to submission

How Ambee supports clinical trials at every stage

Across underwriting, claims, and portfolio decisions

Across feasibility, enrollment, monitoring, and submission

Ambee provides historical environmental baselines, helping trial teams compare sites against the allergen, air quality, and climate conditions most likely to influence study endpoints.

Reduced inter-site endpoint variability
More consistent exposure conditions across cohorts
Lower risk of mid-study protocol amendments

Enrollment and visit scheduling

Ambee provides multi-year seasonality patterns across sites, helping researchers schedule enrolment and assessment visits during historically stable exposure windows.

Improved screening efficiency
Reduced exposure-driven protocol deviations
More stable baseline assessments

Ongoing trial monitoring

Environmental exposure conditions can shift significantly during an active study. Ambee helps teams continuously monitor pollen, AQI, wildfire smoke, and severe weather conditions across investigational sites throughout the trial period.

Prospective exposure-risk monitoring
Improved protocol oversight
Stronger endpoint integrity during data collection

Data interpretation and submission readiness

Ambee provides a traceable environmental exposure record with site-level statistical baselines that can be integrated into endpoint interpretation and regulatory documentation.

Reduced regulatory query risk
Stronger covariate adjustment support
Improved submission readiness
Case study

How a global pharma team applied Ambee’s environmental exposure data to trials

Dermatology, respiratory, and allergic disease trials measure endpoints that respond to ambient conditions. Symptom severity, flare frequency, and patient-reported outcomes can shift with pollen, air quality, temperature, and humidity, complicating efficacy interpretation across sites.
Ambee mapped each participant's location against historical, present, and forecast exposure at the allergen and pollutant level, building a longitudinal exposure profile tied to participant ID,

That exposure profile can support:

Regression models with environmental covariates

Lag-effect analysis on symptom outcomes

Exposure-based cohort stratification

Site-level comparability checks across regions

Across sites in Europe, North America, Japan, and the tropics, this reduced confounding and supported cleaner efficacy interpretation.

Ambee quantifies environmental exposure variability before it becomes endpoint heterogeneity
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